解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Dermatophytes are the primary causative agent of dermatophytoses, a disease that affects billions of individuals worldwide. Trichophyton rubrum is the most common of the superficial fungi. Although T. rubrum is a recognized pathogen for humans, little is known about how its transcriptional pattern is related...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-255
更新日期:2006-10-11 00:00:00
abstract:BACKGROUND:RNA amplification is necessary for profiling gene expression from small tissue samples. Previous studies have shown that the T7 based amplification techniques are reproducible but may distort the true abundance of targets. However, the consequences of such distortions on the ability to detect biological vari...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-252
更新日期:2006-10-09 00:00:00
abstract:BACKGROUND:Abnormalities of pre-mRNA splicing are increasingly recognized as an important mechanism through which gene mutations cause disease. However, apart from the mutations in the donor and acceptor sites, the effects on splicing of other sequence variations are difficult to predict. Loosely defined exonic and int...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-243
更新日期:2006-09-22 00:00:00
abstract:BACKGROUND:Carrot (Daucus carota) is a major food crop in the US and worldwide. Its capacity for storage and its lifecycle as a biennial make it an attractive species for the introduction of foreign genes, especially for oral delivery of vaccines and other therapeutic proteins. Until recently efforts to express recombi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-222
更新日期:2006-08-31 00:00:00
abstract:BACKGROUND:Complete or near-complete genomic sequence information is presently only available for a few plant species representing a large phylogenetic diversity among plants. In order to effectively transfer this information to species lacking sequence information, comparative genomic tools need to be developed. Molec...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-207
更新日期:2006-08-14 00:00:00
abstract:BACKGROUND:The Abeta-binding alcohol dehydrogenase/17beta-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10) is an enzyme involved in pivotal metabolic processes and in the mitochondrial dysfunction seen in the Alzheimer's disease. Here we use comparative genomic analyses to study the evolution of the HADH2 gene encodin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-202
更新日期:2006-08-09 00:00:00
abstract:BACKGROUND:Helicobacter pylori is presumed to be co-evolved with its human host and is a highly diverse gastric pathogen at genetic levels. Ancient origins of H. pylori in the New World are still debatable. It is not clear how different waves of human migrations in South America contributed to the evolution of strain d...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-191
更新日期:2006-07-27 00:00:00
abstract:BACKGROUND:Genomic approaches provide unique opportunities to study interactions of insects with their pathogens. We developed a cDNA microarray to analyze the gene transcription profile of the lepidopteran pest Spodoptera frugiperda in response to injection of the polydnavirus HdIV associated with the ichneumonid wasp...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-160
更新日期:2006-06-21 00:00:00
abstract:BACKGROUND:HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins. HSP90 proteins have been found in a variety of organisms suggesting that they are ancient and conserved. In this study we investigate ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-156
更新日期:2006-06-17 00:00:00
abstract:BACKGROUND:Wheat is an excellent species to study freezing tolerance and other abiotic stresses. However, the sequence of the wheat genome has not been completely characterized due to its complexity and large size. To circumvent this obstacle and identify genes involved in cold acclimation and associated stresses, a la...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-149
更新日期:2006-06-13 00:00:00
abstract:BACKGROUND:Approximately 11 Mb of finished high quality genomic sequences were sampled from cattle, dog and human to estimate genomic divergences and their regional variation among these lineages. RESULTS:Optimal three-way multi-species global sequence alignments for 84 cattle clones or loci (each >50 kb of genomic se...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-140
更新日期:2006-06-07 00:00:00
abstract:BACKGROUND:Tubulin isotypes and expression patterns are highly regulated in diverse organisms. The genome sequence of the protozoan parasite Leishmania major contains three distinct beta-tubulin loci. To investigate the diversity of beta-tubulin genes, we have compared the published genome sequence to draft genome sequ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-137
更新日期:2006-06-06 00:00:00
abstract:BACKGROUND:There is no effective method to obtain genome information from single-celled unculturable organisms such as radiolarians. Even worse, such organisms are often very difficult to collect. Sequence analysis of 18S rDNA has been carried out, but obtaining the data has been difficult and it has provided a rather ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-135
更新日期:2006-06-02 00:00:00
abstract:BACKGROUND:Functional analysis of the catfish genome will be useful for the identification of genes controlling traits of economic importance, especially innate disease resistance. However, this species lacks a platform for global gene expression profiling, so we designed a first generation high-density oligonucleotide...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-134
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Butterfly wing color patterns are a key model for integrating evolutionary developmental biology and the study of adaptive morphological evolution. Yet, despite the biological, economical and educational value of butterflies they are still relatively under-represented in terms of available genomic resources....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-130
更新日期:2006-05-31 00:00:00
abstract:BACKGROUND:The autism spectrum encompasses a set of complex multigenic developmental disorders that severely impact the development of language, non-verbal communication, and social skills, and are associated with odd, stereotyped, repetitive behavior and restricted interests. To date, diagnosis of these neurologically...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-118
更新日期:2006-05-18 00:00:00
abstract:BACKGROUND:The completed sequence of the Anopheles gambiae genome has enabled genome-wide analyses of gene expression and regulation in this principal vector of human malaria. These investigations have created a demand for efficient methods of cataloguing and analyzing the large quantities of data that have been produc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-116
更新日期:2006-05-17 00:00:00
abstract:BACKGROUND:Screening for differentially expressed genes on the genomic scale and comparative analysis of the expression profiles of orthologous genes between species to study gene function and regulation are becoming increasingly feasible. Expressed sequence tags (ESTs) are an excellent source of data for such studies ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-86
更新日期:2006-04-21 00:00:00
abstract:BACKGROUND:Staphylococcus aureus or MRSA (Methicillin Resistant S. aureus), is an acquired pathogen and the primary cause of nosocomial infections worldwide. In S. aureus, teichoic acid is an essential component of the cell wall, and its biosynthesis is not yet well characterized. Studies in Bacillus subtilis have disc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-74
更新日期:2006-04-05 00:00:00
abstract:BACKGROUND:Intergenic splicing resulting in the combination of mRNAs sequences from distinct genes is a newly identified mechanism likely to contribute to protein diversity. Few cases have been described, most of them involving neighboring genes and thus suggesting a cotranscription event presumably due to transcriptio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-71
更新日期:2006-04-04 00:00:00
abstract:BACKGROUND:The question of whether synonymous codon choice is affected by cellular tRNA abundance has been positively answered in many organisms. In some recent works, concerning the human genome, this relation has been studied, but no conclusive answers have been found. In the human genome, the variation in base compo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-67
更新日期:2006-04-03 00:00:00
abstract:BACKGROUND:The increasing use of DNA microarrays for genetical genomics studies generates a need for platforms with complete coverage of the genome. We have compared the effective gene coverage in the mouse genome of different commercial and noncommercial oligonucleotide microarray platforms by performing an in-house g...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-58
更新日期:2006-03-21 00:00:00
abstract:BACKGROUND:The Cleavage Stimulation Factor (CstF) is a required protein complex for eukaryotic mRNA 3'-processing. CstF interacts with 3'-processing downstream elements (DSEs) through its 64-kDa subunit, CstF-64; however, the exact nature of this interaction has remained unclear. We used EST-to-genome alignments to ide...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-55
更新日期:2006-03-16 00:00:00
abstract:BACKGROUND:Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cellular function. Most metazoan proteins are composed of structural and/or functional domains, of which many appear in multiple proteins. Once a domain is characterized in on...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-48
更新日期:2006-03-13 00:00:00
abstract:BACKGROUND:The ribosome is a central player in the translation system, which in mammals consists of four RNA species and 79 ribosomal proteins (RPs). The control mechanisms of gene expression and the functions of RPs are believed to be identical. Most RP genes have common promoters and were therefore assumed to have a ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-37
更新日期:2006-02-28 00:00:00
abstract:BACKGROUND:Genome research in farm animals will expand our basic knowledge of the genetic control of complex traits, and the results will be applied in the livestock industry to improve meat quality and productivity, as well as to reduce the incidence of disease. A combination of quantitative trait locus mapping and mi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-36
更新日期:2006-02-27 00:00:00
abstract:BACKGROUND:Microarray data analysts commonly filter out genes based on a number of ad hoc criteria prior to any high-level statistical analysis. Such ad hoc approaches could lead to conflicting conclusions with no clear guidance as to which method is most likely to be reproducible. Furthermore, the number of tests perf...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-33
更新日期:2006-02-22 00:00:00
abstract:BACKGROUND:An underlying tenet of the epigenetic code hypothesis is the existence of protein domains that can recognize various chromatin structures. To date, two major candidates have emerged: (i) the bromodomain, which can recognize certain acetylation marks and (ii) the chromodomain, which can recognize certain meth...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-6
更新日期:2006-01-16 00:00:00
abstract:BACKGROUND:The Engrailed Homology 1 (EH1) motif is a small region, believed to have evolved convergently in homeobox and forkhead containing proteins, that interacts with the Drosophila protein groucho (C. elegans unc-37, Human Transducin-like Enhancers of Split). The small size of the motif makes its reliable identifi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-169
更新日期:2005-11-27 00:00:00
abstract:BACKGROUND:The genomic organisation of the Major Histocompatibility Complex (MHC) varies greatly between different vertebrates. In mammals, the classical MHC consists of a large number of linked genes (e.g. greater than 200 in humans) with predominantly immune function. In some birds, it consists of only a small number...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-152
更新日期:2005-11-04 00:00:00
abstract:BACKGROUND:It is becoming apparent that perhaps as much as half of the genome of the human blood fluke Schistosoma mansoni is constituted of mobile genetic element-related sequences. Non-long terminal repeat (LTR) retrotransposons, related to the LINE elements of mammals, comprise much of this repetitive component of t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-154
更新日期:2005-11-04 00:00:00
abstract:BACKGROUND:To date several studies have sought to catalog the full suite of antibodies that humans naturally produce against single antigens or other specificities (repertoire). Here we analyze the properties of all sequenced repertoires in order to better understand the specificity of antibody responses. Specifically,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-148
更新日期:2005-10-28 00:00:00
abstract:BACKGROUND:Ser/Thr/Tyr kinases (STYKs) commonly found in eukaryotes have been recently reported in many bacterial species. Recent studies elucidating their cellular functions have established their roles in bacterial growth and development. However functions of a large number of bacterial STYKs still remain elusive. Th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-129
更新日期:2005-09-19 00:00:00
abstract:BACKGROUND:The trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous leishmaniasis, African sleeping sickness, and Chagas disease. These protozoa possess complex life cycles that involve development in mammalian and insect hosts, ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-127
更新日期:2005-09-15 00:00:00
abstract:BACKGROUND:Research using the model system Xenopus laevis has provided critical insights into the mechanisms of early vertebrate development and cell biology. Large scale sequencing efforts have provided an increasingly important resource for researchers. To provide full advantage of the available sequence, we have ana...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-123
更新日期:2005-09-14 00:00:00
abstract:BACKGROUND:We use an approach based on Factor Analysis to analyze datasets generated for transcriptional profiling. The method groups samples into biologically relevant categories, and enables the identification of genes and pathways most significantly associated to each phenotypic group, while allowing for the partici...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-109
更新日期:2005-08-17 00:00:00
abstract:BACKGROUND:Variation in gene expression between two Drosophila melanogaster strains, as revealed by transcriptional profiling, seldom corresponded to variation in proximal promoter sequence for 34 genes analyzed. Two sets of protein-coding genes were selected from pre-existing microarray data: (1) those whose expressio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-110
更新日期:2005-08-17 00:00:00
abstract:BACKGROUND:At least 18 replication-dependent histone H2a genes are distributed in 3 Hist gene clusters on different chromosomes of the mouse genome. In this analysis we designed specific PCR primers for each histone H2a transcript and studied the expression levels and patterns using quantitative RT-PCR (qRT-PCR). In ad...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-108
更新日期:2005-08-13 00:00:00
abstract:BACKGROUND:Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-98
更新日期:2005-07-13 00:00:00
abstract:BACKGROUND:Phanerochaete chrysosporium, the model white rot basidiomycetous fungus, has the extraordinary ability to mineralize (to CO2) lignin and detoxify a variety of chemical pollutants. Its cytochrome P450 monooxygenases have recently been implied in several of these biotransformations. Our initial P450 cloning ef...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-92
更新日期:2005-06-14 00:00:00